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In the brain, dysfunction of GSH synthesis leading to GSH depletion exacerbates oxidative stress, which is linked to a pathogenesis of aging-related neurodegenerative diseases

Through a process called S-glutathionylation, glutathione also regulates major DNA repair proteins, such as the Ku70/Ku80 heterodimer used in Non-Homologous End Joining (NHEJ) to repair double-strand breaks

doi: 10.1016/j.molcel.2020.11.024, 130 YuH.ChangQ.SunT.HeX.WenL.AnJ.et al

Sleep is even critical for mood regulation, which is why studies link insufficient sleep with increased levels of anxiety and depression

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Andersson, M